Is this the healthy habits or getting old thread?
Took first dose of zepbound today. Let’s see what happens.
Long post, so I apologize to everyone in advance.
I've been overweight most of my life. I'm 41 now, and I've had issues with my weight as long as I can remember. Probably starting at around 10. My dad working afternoon shift, six days a week so suffice to say he wasn't around a lot and my mom was not an attentive parent. Translation, I ate whatever and whenever I wanted.
That's not to say that I'm "blaming" this all on them. I'm 41, I've been an adult for a long time and I've had plenty of time to fix this on my own. I've tried multiple times with varying degrees of success but I've always backslid.
My wife has also struggled with her weight, though not to the same extremes that I have. About 18 months ago, she was prescribed Wegovy and she's had amazing success. She's lost 100 pounds and is looking & feeling the best she ever has in her adult life. I'm incredibly proud of her and happy for her and her success.
About six months ago, I decided to engage my doctor in discussing starting something like Wegovy or Zepbound. I had the bloodwork done, and the story was that I was in a bad gray area. My A1C and glucose levels were "too high" for Wegovy/Zepbound to be approved, but not "high enough" for Mounjaro/Ozempic, according to my PCP. This lead me to visit the weight loss specialist doctor that my wife sees. She disagreed with my PCP RE my A1C being "high enough" and prescribed Mounjaro.
I took the first injection almost exactly two months ago. The first month consisted of 2.5 mg injections once a week. I had no issues in the first month, and lost about 8 pounds. The doctor was satisfied with this progress, and bumped me up from the starter dose to 5mg per week to step up.
This is where all hell kind of broke loose.
Week 1 on the step up dose was fine. I didn't feel any differently than I did on the starter dose. Week 2? Entirely different story. I took the injection around 5am on Friday morning. Waking at around 7am on Saturday morning, I had terrible nausea and upper-mid stomach pain. Terrible bloating. I didn't even suspect the Mounjaro, I just thought I had a stomach bug, foodborne illness, etc. Spent all of Saturday day/early Sunday morning with vomiting, diarrhea and terrible nausea along with that continued upper gastric pain and pressure. After about 28 hours or so, it subsided and I pretty quickly went back to normal.
Week 3? Again, no issues. I continue on thinking I had a stomach bug. Week 4? Disaster. I took the injection around 9pm on Thursday night. Around 7pm on Friday, again. The diarrhea, nausea, vomiting, pressure. Over the next 12 hours, I vomited no less than a dozen times. I couldn't hold down sips of water without vomiting again. I took a shower in the middle of the night just to try to feel differently, trying anything. I nearly fainted in the shower, made it out just in time to sit in the toilet, soaking wet, puking in the trash can again. By around 7:30am the next morning I'd had enough and called 911. I was legitimately scared, insanely dehydrated and could not stand to feel that way anymore. I got IV nausea meds and fluids in the ambulance and a repeat round of both at the hospital. They tested for Pancreatitis, a (fairly) common side effect of these injections but thankfully that was negative. After 3 hours or so, they sent me home with a prescription for Zofran and instructions of a BRAT diet. As of now, Wednesday, I'm just now starting to (kind of) eat normally again.
Now, this isn't entirely on the meds. I did things poorly. One thing that I did which is a cardinal sin on these meds is that (on both occasions), I ate and then lied down. Almost immediately. I know in hindsight how stupid that is, but I didn't get to be obese at 41 by making quality food decisions. Additionally, when taking the injections, I was only usually eating two meals a day. Another cardinal sin, apparently. Your body needs protein 3x a day on these meds, whether you feel hungry or not, in order to regulate properly. Basically, I did most everything wrong and it resulted in disaster. In 8 weeks on this drug, I've lost 32 pounds. The desired pace for weight loss on Mounjaro is about half that.
So now, I'm off Mounjaro for the time being. My doctor wants me to refocus on eating correctly and keeping the weight that I've lost off and we'll revisit the possibility of Mounjaro or another medication in the next few months. I say all of this not to scare you (or anyone else) off of Zepbound, Mounjaro or any other drugs of this type. I guess the moral of my story is for you (and anyone else who may be using or thinking of using them) to PLEASE carefully consider the instructions the doctors give you. The way I felt the way I went to the hospital that morning I wouldn't wish on my worst enemy.